The aim of this study was to formulate ketoprofen microsponges by emulsion solvent diffusion method and formulation of hydrogel containing ketoprofen microsponges. The prepared microsponges were found to be discrete, spherical particles and were free flowing with particle size range of 58.9 to 89.5 µm. Microsponge with maximum drug entrapment was selected and formulated into hydrogel using carbopol 934 and sodium CMC as gelling agents. The formulated hydrogels were found transparent and smooth. All the gel formulations showed good homogeneity with absence of lumps. The hydrogel formulations exhibited sustained drug release in pH 7.4 phosphate buffer. The In-vitro release for all the prepared gel formulations fitted best to first order and matrix model that confirmed that mechanism of drug release was found to be diffusion process. The prepared gel formulations does not show any changes in physical appearance and no significant variation in pH and drug content was observed in accelerated stability studies.
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